Valorization of agro-wastes for the biosynthesis and characterization of polyhydroxybutyrate by sp. isolated from rice bran dumping yard.

Investigations have been made to determine the usage of inexpensive agro-waste products as an alternative carbon source for the production of degradable bacterial polyester. Among 33 bacterial isolates, a gram-positive bacterium PPECLRB-16 isolated from rice bran dumping yard was found to accumulate a relatively higher quantity of PHB and identified as sp. through 16S rRNA gene sequence analysis.

Human iPSC-Derived Neuronal Cells From -Mutated Patients Reveal Altered Expression of Neurodevelopmental Gene Networks.

A recurrent mutation in the transcriptional corepressor is associated with neurodevelopmental disabilities in children (Beck et al., 2016, 2019; Sommerville et al., 2017).

Statistical augmentation of polyhydroxybutyrate production by Isoptericola variabilis: Characterization, moulding, in vitro cytocompatibility and biodegradability evaluation.

This study aimed to explore the production of polyhydroxybutyrate (PHB), a polyhydroxyalkanoate (PHA), which has been widely considered as a potential substitute for the synthetic polymers. Among 53 actinomycete isolates, 11 of them were found to be PHB positive and the quantity of PHB from the positive isolates varied from 10.5 to 29.

A pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity.

We previously reported a pathogenic de novo p.R342W mutation in the transcriptional corepressor CTBP1 in four independent patients with neurodevelopmental disabilities [1]. Here, we report the clinical phenotypes of seven additional individuals with the same recurrent de novo CTBP1 mutation.