Publications by authors named "G Chevreux"
Corrigendum to Multiomic analysis in fibroblasts of patients with inborn errors of cobalamin metabolism reveals concordance with clinical and metabolic variability [eBioMedicine 99 (2024), 104911].
EBioMedicine
December 2024
Article Synopsis
- - Ciliates use a programmed genome elimination process involving small RNAs (scnRNAs) that help remove transposable elements (TEs) from the somatic nucleus during development.
- - scnRNAs are produced from the germline genome and transported to the maternal somatic nucleus, where scnRNAs corresponding to germline-specific sequences are selected for degradation.
- - The study identifies Gtsf1 as necessary for the selective degradation of scnRNAs tied to retained sequences, suggesting it works alongside the Ptiwi09 protein in the somatic nucleus to regulate this elimination process through a mechanism similar to microRNA degradation in other organisms.
Purpose: Cluster of differentiation 40 (CD40) is expressed on B-cell acute lymphoblastic leukemia (B-ALL) cases. However, the effect of CD40 activation on B-ALL cells has never been tested in vivo.
Experimental Design: The aim of our preclinical study was to investigate the therapeutic potential of a CD40 agonist in the treatment of B-ALL using patient-derived xenograft mouse models.
Protein mycoloylation is a recently identified unusual post-translational modification (PTM) exclusively observed in Mycobacteriales, an order of bacteria that includes several human pathogens. These bacteria possess a distinctive outer membrane, known as the mycomembrane, composed of very long-chain fatty acids called mycolic acids. It has been demonstrated that a few mycomembrane proteins undergo covalent modification with mycolic acids in the model organism through the action of mycoloyltransferase MytC.
View Article and Find Full Text PDFArticle Synopsis
- Understanding RNA targeting to membraneless organelles like P-bodies (PBs) is crucial for revealing their functions in cells.
- This study shows that PBs in HEK293 cells undergo significant changes in RNA content throughout the cell cycle, with different mRNA localization patterns appearing at various stages (G1, S, G2).
- The findings suggest that PBs actively sort mRNAs based on their translation status and characteristics, implying that they play a more dynamic role than merely housing excess untranslated mRNAs.