Publications by authors named "G Ceccarini"
Lipodystrophies (LDs) are rare, complex disorders of the adipose tissue characterized by selective fat loss, altered adipokine profile and metabolic impairment. Sirtuins (SIRTs) are class III NAD-dependent histone deacetylases linked to fat metabolism. SIRT1 plays a critical role in metabolic health by deacetylating target proteins in tissue types including liver, muscle, and adipose.
View Article and Find Full Text PDFPurpose: Bariatric surgery (BS), an effective treatment for severe obesity and its comorbidities, may result in micronutrient and vitamin deficiencies. This monocentric prospective observational study aimed at evaluating the efficacy of a specifically designed vitamin/mineral formula (Bariatrifast, BIOITALIA S.r.
View Article and Find Full Text PDFLipodystrophy syndromes are rare diseases primarily affecting the development or maintenance of the adipose tissue but are also distressing indirectly multiple organs and tissues, often leading to reduced life expectancy and quality of life. Lipodystrophy syndromes are multifaceted disorders caused by genetic mutations or autoimmunity in the vast majority of cases. While many subtypes are now recognized and classified, the disease remains remarkably underdiagnosed.
View Article and Find Full Text PDFSerum levels of adiponectin differentiate generalized lipodystrophies from anorexia nervosa.
J Endocrinol Invest
August 2024
Article Synopsis
- The study aimed to differentiate lipodystrophy from other diseases with similar fat loss symptoms, particularly anorexia nervosa.
- Researchers measured leptin and high molecular weight adiponectin serum concentrations in various patient groups, including those with different types of lipodystrophy and anorexia nervosa.
- Results showed that HMW adiponectin levels were significantly lower in patients with lipodystrophy compared to those with anorexia, suggesting it can help in accurately diagnosing these conditions.
Article Synopsis
- Barraquer-Simons syndrome (BSS) is a rare acquired lipodystrophy leading to significant loss of upper body fat, particularly affecting the face and arms, with a possible autoimmune origin.
- This study evaluated clinical and immunological data from 26 BSS patients to refine diagnostic tools and identify potential triggers or genetic links.
- Key findings revealed most patients experienced fat loss in childhood, with a notable prevalence of autoimmune markers and metabolic conditions, suggesting BSS is commonly connected to other autoimmune diseases.