Publications by authors named "G Castelli Gattinara"
Sore throat represents one of the main causes of antibiotic overprescription in children. Its management is still a matter of debate, with countries considering streptococcal pharyngotonsillitis a benign and self-limiting condition and others advocating for its antibiotic treatment to prevent suppurative complications and acute rheumatic fever. Italian paediatricians frequently prescribe antibiotics on a clinical basis regardless of microbiological results.
View Article and Find Full Text PDFAcute pharyngitis in children and adults: descriptive comparison of current recommendations from national and international guidelines and future perspectives.
Eur J Pediatr
December 2023
Article Synopsis
- * Three main management strategies emerged: one endorsing antibiotics to prevent acute rheumatic fever, another viewing pharyngitis as self-limiting, and a third adjusting treatment based on individual risk for rheumatic fever.
- * The findings highlight inconsistencies across international guidelines, suggesting the need for a unified global approach and further research on cost-effectiveness and local GABHS epidemiology.
Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus Vaccine in Infants 6-7 Months of age: A Phase 1/2 Randomized Trial.
J Infect Dis
January 2024
Article Synopsis
- A study was conducted to evaluate the safety and immune response of a new RSV vaccine (ChAd155-RSV) in infants aged 6-7 months, comparing different doses and an active comparator.* -
- The trial involved 201 infants, with results indicating that the vaccine had a safety profile comparable to existing childhood vaccines, and did not lead to adverse respiratory effects associated with RSV infections.* -
- Higher doses of the ChAd155-RSV vaccine produced stronger immune responses, with increased antibody levels observed after vaccination, especially following the second dose.*
Bronchiolitis is an acute respiratory illness that is the leading cause of hospitalization in young children. This document aims to update the consensus document published in 2014 to provide guidance on the current best practices for managing bronchiolitis in infants. The document addresses care in both hospitals and primary care.
View Article and Find Full Text PDFBackground: Two sequelae of pediatric COVID-19 have been identified, the multisystem inflammatory syndrome in children (MIS-C) and the long COVID. Long COVID is much less precisely defined and includes all the persistent or new clinical manifestations evidenced in subjects previously infected by SARS-CoV-2 beyond the period of the acute infection and that cannot be explained by an alternative diagnosis. In this Intersociety Consensus, present knowledge on pediatric long COVID as well as how to identify and manage children with long COVID are discussed.
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