Publications by authors named "G Castel"
Introduction: Inter- and transdisciplinary research (ITDR) is increasingly promoted to address "wicked problems", particularly in health sectors adopting approaches like Ecohealth. Our Ecohealth-inspired project on rodent-borne diseases, initiated just before the COVID-19 pandemic, provided an opportunity to evaluate ITDR implementation.
Methods: We employed a recently developed semi-quantitative evaluation method to measure our project's success in achieving ITDR and analyzed factors influencing this achievement.
Article Synopsis
- XIST long noncoding RNA plays a key role in X chromosome inactivation in placental mammals but is present on both X chromosomes in early human embryos without silencing them.
- XACT lncRNA accumulates alongside XIST on active X chromosomes and may counteract XIST's functions.
- Research using human embryonic stem cells reveals that XIST modifies chromatin and reduces transcription of X-linked genes, while XACT's absence does not significantly impact XIST’s activity or gene expression, indicating that XIST has a role prior to XCI and highlights a mechanism of temporary X chromosome dosage compensation.
Background: Seoul virus (SEOV) is an orthohantavirus primarily carried by rats. In humans, it may cause hemorrhagic fever with renal syndrome (HFRS). Its incidence is likely underestimated and given the expansion of urban areas, a better knowledge of SEOV circulation in rat populations is called for.
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- Orthohantaviruses, primarily transmitted by rodents, cause serious illnesses such as hemorrhagic fever with renal syndrome in Eurasia and hantavirus pulmonary syndrome in the Americas, with no effective treatments or vaccines currently available.
- The study focused on the Puumala virus (PUUV), carried by bank voles, which causes a milder form of HFRS; researchers developed a hybrid-capture method for complete genomic sequencing of PUUV isolates, revealing valuable information about nucleotide diversity and lineage.
- The findings offer crucial insights into PUUV evolution and epidemiology in Northern Sweden, highlighting the panel's diagnostic potential that could improve understanding of Orthohantavirus transmission routes.
Objective: A large and unprecedented outbreak of an attenuated form of hemorrhagic fever with renal syndrome called nephropathia epidemica (NE) and caused by Puumala virus (PUUV) occurred in 2021 in the southern Jura Mountains (France) leading to numerous hospitalizations. The aim of this study was to investigate the circulation of PUUV in its animal reservoir at the time of this outbreak.
Methods: We conjointly surveyed bank vole relative abundance, small mammal community composition, and PUUV circulation in bank voles (seroprevalence and genetic diversity) in the Jura NE epidemic area, between 2020 and 2022.