Publications by authors named "G Casals"
Pain is a frequent and disturbing symptom among hemodialysis patients. Protein-bound uremic toxins (PBUTs) are related to cardiovascular and overall mortality, and they are difficult to remove with current hemodialysis treatments. The PBUT displacers, such as furosemide, tryptophan, or ibuprofen, may be promising new strategies for improving their clearance.
View Article and Find Full Text PDFHepatic insulin resistance (IR) is often said to be "pathway-selective" with preserved insulin stimulation of lipogenesis (DNL) despite attenuated insulin signaling toward glucose metabolism. However, DNL has not been assessed in models of liver-specific IR. We studied mice with differential tissue-specific lipid-induced IR achieved by different durations of high-fat diet (HFD) feeding.
View Article and Find Full Text PDFIntroduction: Distinct androgen formulations have been used as gender-affirming hormone treatment, but little is known about the specific changes that may occur in the ovary depending on the testosterone preparation used. The study aims to evaluate the histological modifications of the ovarian tissue and the hormonal changes after gender-affirming surgery based on the testosterone preparation employed, such as testosterone cypionate or undecanoate.
Design: Unicenter transversal cohort study.
Comparative Effects of Acetate- and Citrate-Based Dialysates on Dialysis Dose and Protein-Bound Uremic Toxins in Hemodiafiltration Patients: Exploring the Impact of Calcium and Magnesium Concentrations.
Toxins (Basel)
October 2024
Article Synopsis
- Modern hemodialysis typically uses acetate as a buffer, which has been associated with chronic inflammation, while citrate is being explored as a potential alternative for dialysate.
- This study compares the efficacy of acetate- and citrate-based dialysates in terms of dialysis efficiency and the removal of protein-bound uremic toxins in patients undergoing hemodiafiltration.
- Results showed no significant differences in overall dialysis doses or most toxin reduction, but lower calcium and magnesium citrate dialysates led to better clearance of p-cresyl sulfate, indicating a need for further research to optimize dialysate formulas.
Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by infection.
Gut Microbes
October 2024
Article Synopsis
- Short-chain fatty acids (SCFAs) are essential for gut health and immune function, with lower levels seen in patients suffering from dysbiosis, particularly those with Clostridium difficile infection (CDI).
- Current methods to measure SCFAs in stool samples lack consistency and often overlook factors like water, fiber content, and bacterial counts, which are crucial for accurate analysis.
- The study demonstrates that normalizing SCFA concentrations by bacterial count enhances the differentiation between healthy and dysbiotic samples, particularly highlighting butyrate as the most effective marker for distinguishing between healthy and unhealthy gut microbiota.