Publications by authors named "G Caprio"
Purpose: To describe the clinical characteristics and outcomes of patients with nosocomial pneumonia (NP) caused by carbapenem-resistant Gram-negative bacilli (CR-GNB) and to compare them to patients with NP caused by carbapenem-susceptible (CS)-GNB.
Methods: Prospective observational multicenter study including patients with bacteremic NP caused by GNB from the ALARICO Network (June 2018-January 2020). The primary outcome measure was 30-day mortality.
Objective: To investigate the association between oral contraceptive (OC) pill use and the risk of developing multiple sclerosis (MS), attempting to address the limitations present in previous studies that produced conflicting results.
Design: A population-based cohort study using data from the UK Biobank.
Patients: The study included 181,058 women of white ethnicity born in England between 1937 and 1970, among which 1,131 had an MS diagnosis.
Background: Previous investigations into multiple sclerosis (MS) risk factors predominantly relied on retrospective studies, which do not consider different follow-up times and assume a constant risk effect throughout lifetime.
Objective: We aimed to evaluate the impact of genetic and early life factors on MS diagnosis by employing a time-to-event analysis in a prospective cohort.
Methods: We used the UK Biobank data, considering the observation period from birth up to 31 December 2022.
Background: Migrants, mainly undocumented and low-income refugees, are at high risk of hepatitis C virus (HCV) infection, but are a difficult-to-reach and to-treat population. The aim of the study was to evaluate the effectiveness of a test and treat model with direct-acting antiviral for HCV infection in these migrants coming from low-income and living in southern Italy.
Methods: A prospective, multicenter, collaborative study based on a four-phase-program (educational counseling, screening, linkage-to-care and treatment) was designed in southern Italy; the study started in June 2018, was stopped in February 2020 because of the outbreak of SARS-CoV2 infection in Italy and was resumed in February 2021 until November 2021.
Article Synopsis
- Carbapenemase-producing Enterobacteriaceae (CPE), specifically New Delhi metallo-β-lactamase (NDM) producing K. pneumoniae, pose a rising threat to global health due to limited treatment options.
- This study evaluated the effectiveness of the meropenem and fosfomycin combination against 20 clinical isolates, finding that the combination was synergistic in 95% of the tested strains.
- The research suggests the importance of performing in vitro synergy testing for multidrug-resistant infections, as combination therapies can provide alternatives and potentially lower antibiotic costs.