Publications by authors named "G Candotti"
: This study investigates which demographic, clinical and pathological factors of women with early-stage presurgical EC could be considered risk factors for the presence of different subtypes of metastases in sentinel lymph nodes (SLNs). : This is a retrospective single-center study that collected data between December 2015 and April 2024. EC patients who underwent total hysterectomy with salpingo-oophorectomy and SLN mapping with indocyanine green (ICG) were recorded.
View Article and Find Full Text PDFBackground: The intrauterine manipulator used during a hysterectomy for endometrial cancer has been suggested as a reason for worsening oncologic outcomes. However, only a few non-randomized retrospective studies have investigated this association.
Primary Objectives: To compare 4-year recurrence-free survival in the group of patients who undergo hysterectomy using an intrauterine manipulator with that of those who undergo hysterectomy without it.
Article Synopsis
- Immunotherapy shows limited benefits for patients with epithelial ovarian cancer (EOC), highlighting the need to better understand local immune dynamics and pathways that suppress T-cell activity against tumors.
- The study analyzed tumor samples from 48 EOC patients to investigate the immune cell composition, focusing on tumor-infiltrating lymphocytes (TILs) using various research methods.
- Findings revealed a unique population of activated T cells in EOC tumors and identified the role of macrophages in both stimulating and inhibiting immune responses, suggesting potential targets for improving immunotherapy efficacy.
Evidence indicates that different pathways of malignant degeneration underlie the development of endometriosis-associated ovarian tumors of endometrioid and clear cell histotypes. The aim of this study was to compare data from patients affected by these two histotypes to investigate the hypothesis of a dichotomy in the histogenesis of these tumors. Clinical data and tumor characteristics of 48 patients who were diagnosed with either pure clear cell ovarian cancer and mixed endometrioid-clear cell ovarian cancer arising from endometriosis (ECC, = 22) or endometriosis-associated endometrioid ovarian cancer (EAEOC, = 26) were compared.
View Article and Find Full Text PDFRadiotherapy has been increasingly considered as an active treatment to combine with other approaches (i.e., surgery, chemotherapy, and novel target-based drugs) in ovarian cancers to palliate symptoms and/or to prolong chemotherapy-free intervals.
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