Knowledge and attitudes of primary care physicians regarding acromegaly: a survey study with multinational participation.

Background: Acromegaly is a disease with high morbidity and mortality rates. The role of primary care physicians is very important in the early diagnosis of acromegaly. The present study aims to determine the knowledge and attitudes of primary care physicians about acromegaly in different countries worldwide.

The Effect of Reflexology Socks in the Management of Opioid-Induced Constipation: A Randomized Controlled Trial.

Background: Constipation is an important symptom that is common in patients using opioids and leads to major health problems among patients. Reflexology is one of the approaches utilized to manage constipation.

Objective: To examine the effect of reflexology socks on constipation in patients with opioid-induced constipation.

TTF2 promotes replisome eviction from stalled forks in mitosis.

When cells enter mitosis with under-replicated DNA, sister chromosome segregation is compromised, which can lead to massive genome instability. The replisome-associated E3 ubiquitin ligase TRAIP mitigates this threat by ubiquitylating the CMG helicase in mitosis, leading to disassembly of stalled replisomes, fork cleavage, and restoration of chromosome structure by alternative end-joining. Here, we show that replisome disassembly requires TRAIP phosphorylation by the mitotic Cyclin B-CDK1 kinase, as well as TTF2, a SWI/SNF ATPase previously implicated in the eviction of RNA polymerase from mitotic chromosomes.

Evidence-Based Nonpharmacological Symptom Management of Palliative Care in Advanced and Metastatic Cancer Patients: A Systematic Review.

The aim of this systematic review is to provide reliable, high-quality data with an evidence-based, up-to-date overview of the use of nonpharmacologic interventions in the management of symptoms in advanced cancer patients with metastatic disease. A comprehensive literature search was performed by searching PubMed, EBSCO, Cochrane, and Google Scholar databases. "Nonpharmacologic," "palliative care," and "cancer" were the three main terms combined with the main symptoms of cancer palliative care such as "pain," "fatigue," "nausea and vomiting," "psychosocial distress," "loss of appetite," "dyspnea," "constipation," and "drowsiness," and each symptom was searched separately.