Publications by authors named "G Camilleri"
Article Synopsis
- * KRAS mutations, which are common in CRC, have historically been difficult to target, but recent drug developments have introduced several KRAS inhibitors, including both covalent and non-covalent types.
- * Clinical trials are underway to test the effectiveness of these KRAS inhibitors, either alone or with other treatments, despite challenges like resistance and tumor diversity, indicating that these inhibitors could significantly enhance CRC patient outcomes in the future.
Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies).
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- The study evaluates the prevalence and progression of malnutrition and sarcopenia in patients with metastatic breast cancer, revealing that both conditions are common and often overlap.
- It identifies risk factors, noting that patients over 60 are more likely to experience solitary malnutrition and its combinations, but not solitary sarcopenia.
- The findings indicate that solitary malnutrition is linked to poorer overall survival, while solitary sarcopenia and combined malnutrition/sarcopenia do not show the same association.