Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics.

Background Nuclear-to-mitochondrial communication regulating gene expression and mitochondrial function is a critical process following cardiac ischemic injury. In this study, we determined that cyclin C, a component of the Mediator complex, regulates cardiac and mitochondrial function in part by modifying mitochondrial fission. We tested the hypothesis that cyclin C functions as a transcriptional cofactor in the nucleus and a signaling molecule stimulating mitochondrial fission in response to stimuli such as cardiac ischemia.

New Scheimpflug camera device in measuring corneal power changes after myopic laser refractive surgery.

Purpose: To assess the accuracy of a combined Scheimpflug camera-Placido disk device (Sirius, CSO, Italy) in evaluating corneal power changes after myopic photorefractive keratectomy (PRK).

Methods: Two hundred and thirty-seven eyes of 237 patients that underwent myopic PRK with a refractive error, measured as spherical equivalent, ranging from -10.75 D to -0.

Body mass changes during long-duration spaceflight.

Background: During early spaceflights, many crewmembers did not meet their caloric requirements and consequently lost body mass during flight, as assessed by a decrease in postflight body mass. Maintaining body mass during spaceflight is crucial for maintaining crew health and monitoring body mass is thus important to medical operations as well as being a key component of human research. Determining body mass becomes difficult in a microgravity environment.

Medial artery calcification of uremic patients: a histological, histochemical and ultrastructural study.

Recent findings suggest that vascular calcification (VC) is an active process similar to bone mineralization, the vascular smooth muscle cells (VSMCs) undergoing phenotypic differentiation into osteoblastic cells and synthesizing calcification-regulating proteins found in bone. This study has investigated the VC process of uremic patients, with a morphologic approach. Epigastric artery samples from 49 uremic, non-diabetic patients were taken during kidney transplantation.