ABC score is a better predictor for 30-day mortality in upper gastrointestinal bleeding: A prospective single-center study.

Background: Acute upper gastrointestinal bleeding (UGIB) still has a mortality rate of about 10%. Several pre-endoscopy scoring systems have been developed to predict the outcome, but none accurately predict mortality. The present study was aimed at comparing the new ABC score (age, blood tests and comorbidities) with other pre-existing scoring systems to predict mortality.

Decoding differentially expressed genes to identify potential immunity associated biomarkers in Tuberculosis: An integrative bioinformatics approach.

Tuberculosis (TB) poses a significant threat to the Indian population, with India accounting for 20 % of the global TB cases. The current study aims to identify molecular biomarkers for better diagnostics by comparing the transcriptome signatures of healthy individuals against TB-affected individuals. Next-generation sequencing (NGS) tools were used to identify critical differentially expressed genes (DEGs).

Modulation of morphine antinociceptive and rewarding effect by mirtazapine in an animal model of osteoarthritic pain.

People with chronic pain mitigate their suffering by the action of opioids. Adverse reactions aside, opioids are not exempt from potential complications like addiction and abuse, which have posed a global public health problem lately. Finding new therapeutic strategies to improve analgesia and to reduce opioid side effects has become a priority.

Challenges and Triumphs in Enterocutaneous Fistula Management: A Case Report of Complex Surgical Intervention and Multidisciplinary Care.

Enterocutaneous fistulas (ECF) present complex challenges following abdominal surgery, involving abnormal communication between the gastrointestinal system and skin. We report an intriguing case of a 50-year-old female with a history of appendiceal perforation, primarily managed by right hemicolectomy with ileotransverse anastomosis, which led to an anastomotic leak and eventually an ECF. Failed conservative management, prompting re-exploratory laparotomy revealing extensive adhesions and iatrogenic enterotomies secondary to attempted adhesiolysis, led to multiple fistulae, further complicated by failed abdominal closure leading to a large abdominal wound to be managed along with the numerous enteroatmospheric fistulae.