Publications by authors named "G C Salomon"
Background: Myocarditis is an inflammation of the heart muscle most often caused by viral infections. Sex differences in the immune response during myocarditis have been well described but upstream mechanisms in the heart that might influence sex differences in disease are not completely understood.
Methods: Male and female BALB/c wild type mice received an intraperitoneal injection of heart-passaged coxsackievirus B3 (CVB3) or vehicle control.
Article Synopsis
- The study aimed to evaluate the surgical and cancer-related results of salvage radical prostatectomy (sRP) after treatment failure in patients who initially received primary therapy.
- Researchers analyzed data from patients who underwent either primary or salvage surgery, comparing outcomes like recurrence-free survival, surgical complications, and recovery times.
- Findings indicated that sRP performed by experienced surgeons yielded similar outcomes in terms of cancer control and recovery compared to primary radical prostatectomy, though the study's retrospective design was a notable limitation.
: Progression to metastatic castration-resistant prostate cancer (mCRPC) is defined either biochemically, radiographically or both. Moreover, staging for mCRPC can be performed either conventionally or with molecular imaging such as prostate-specific membrane antigen computer tomography (PSMA-PET/CT). : We relied on the Frankfurt Metastatic Cancer Database of the Prostate (FRAMCAP) database to compare progression-free (PFS) and overall survival (OS) outcomes regarding the cause of castration resistance and the staging modality used.
View Article and Find Full Text PDFIdentifying the best candidate for focal therapy: a comprehensive review.
Prostate Cancer Prostatic Dis
October 2024
Background: Despite the evidence supporting the use of focal therapy (FT) in patients with localized prostate cancer (PCa), considerable variability exists in the patient selection criteria across current studies. This study aims to review the most recent evidence concerning the optimal approach to patient selection for FT in PCa.
Methods: PubMed database was systematically queried for studies reporting patient selection criteria in FT for PCa before December 31, 2023.
Article Synopsis
- Biparametric MRI (bpMRI) may serve as a valid alternative to multiparametric MRI (mpMRI) for diagnosing clinically significant prostate cancer (csPCa), as assessed in a large international observer study.
- The study involved 400 mpMRI examinations from four different European centers, where readers evaluated both bpMRI and mpMRI for their ability to accurately diagnose csPCa, finding them to be similarly effective.
- Key findings indicated that bpMRI and mpMRI had comparable diagnostic accuracy (AUROC values) and sensitivity, with bpMRI showing a noninferior performance, though both methods had similar specificity when distinguishing csPCa.