Publications by authors named "G C Pastorino"
Purpose Of Review: Muscle invasive bladder cancer (MIBC) is aggressive and requires radical cystectomy and neoadjuvant therapy, yet over 40% of patients face recurrence. The loss of the bladder also significantly reduces quality of life. Accurate staging, crucial for treatment decisions, is typically done through transurethral resection (TURBT), but inconsistencies in pathology affect diagnosis in 25% of cases.
View Article and Find Full Text PDFPain is an unpleasant sensory and emotional experience. Adequate pain control is often challenging, particularly in patients with chronic pain. Despite advances in pain management, drug addiction, overtreatment, or substance use disorders are not rare.
View Article and Find Full Text PDFFirst Results of NURE-Combo: A Phase II Study of Neoadjuvant Nivolumab and Nab-Paclitaxel, Followed by Postsurgical Adjuvant Nivolumab, for Muscle-Invasive Bladder Cancer.
J Clin Oncol
December 2024
Article Synopsis
- The study aimed to assess the effectiveness and safety of combining nivolumab with nab-paclitaxel as a pre-surgery treatment for patients with muscle-invasive bladder cancer (MIBC), followed by surgery and additional nivolumab therapy.
- A total of 31 patients participated, with a significant portion experiencing severe treatment-related side effects; however, the treatment led to a notable pathologic complete response rate of 32.3% among those evaluated.
- The findings indicate promising outcomes with an 89.8% event-free survival rate after 12 months, suggesting this combination therapy could enhance treatment options for these patients.
Article Synopsis
- Lennox-Gastaut syndrome (LGS) is a severe epilepsy affecting adults and this study explores long-term cognitive and adaptive behavior outcomes in adults with LGS, an area not extensively studied before.
- *The study involved 38 adults with LGS, finding that all participants had low adaptive behavior scores, especially in daily living skills and socialization, with younger diagnosis age linked to worse outcomes.
- *Results showed specific associations between clinical factors (like seizure frequency and EEG abnormalities) with lower adaptive behavior scores, and treatment with cannabidiol was linked to better outcomes compared to benzodiazepines.
Background: The primary aims of our cross-sectional observational study were: (i) to determine the prevalence of depressive symptoms in children and adolescents with epilepsy compared to controls and (ii) to explore the difference in depressive symptoms in patients with epilepsy only and those with epilepsy and primary headache as a comorbidity. The secondary objective was to explore parental stress levels.
Methods: 68 pediatric patients aged 6-18 years (44 with epilepsy only and 24 with epilepsy and headache) and 50 controls were recruited.