Publications by authors named "G C Moreo"
Oral Health Status among Migrants from Middle- and Low-Income Countries to Europe: A Systematic Review.
Int J Environ Res Public Health
November 2021
Introduction: Economic inequality, political instability and globalization have contributed to the constant growth of the migration phenomenon in recent years. In particular, a total of 4.2 million people migrated to Europe during 2019 and most of them settled in Germany, France and Italy.
View Article and Find Full Text PDFClinical factors associated with death in 3044 COVID-19 patients managed in internal medicine wards in Italy: results from the SIMI-COVID-19 study of the Italian Society of Internal Medicine (SIMI).
Intern Emerg Med
June 2021
During the COVID-19 2020 outbreak, a large body of data has been provided on general management and outcomes of hospitalized COVID-19 patients. Yet, relatively little is known on characteristics and outcome of patients managed in Internal Medicine Units (IMU). To address this gap, the Italian Society of Internal Medicine has conducted a nationwide cohort multicentre study on death outcome in adult COVID-19 patients admitted and managed in IMU.
View Article and Find Full Text PDFEfficacy ozone therapy in reducing oral infection of periodontal disease: a randomized clinical trial.
J Biol Regul Homeost Agents
January 2021
Periodontal diseases are among the most common infectious diseases in the world, caused by pathogenic bacteria that trigger innate, inflammatory, and adaptive immune responses, leading to the destruction of supporting periodontal tissues and, if untreated, tooth loss. The objective of this study was to explore the efficacy of medical device that produced ozonized water (Medica S.r.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how the anticonvulsant diphenylhydantoin and the drug gabapentin affect gene expression related to gingival overgrowth, particularly in human fibroblasts.
- - Both drugs show similar impacts on the expression of genes tied to extracellular matrix formation, increasing production of certain matrix proteins while lowering the activity of enzymes that break down the matrix.
- - The findings support the idea that these medications can directly influence the gums, leading to increased tissue growth and potential gingival hyperplasia.
Article Synopsis
- Drug-induced gingival overgrowth can result from long-term use of three types of systemic medications: anticonvulsants, immunosuppressants, and calcium channel blockers.
- This study specifically looked at how the immunosuppressive drugs cyclosporin A and mycophenolate mofetil affect the function of gingival fibroblasts, which are cells involved in maintaining gum tissue.
- Although neither drug impacted fibroblast cell viability at certain concentrations, both treatments led to noticeable changes in gene expression related to extracellular matrix components, indicating a potential link to gingival enlargement that requires further exploration.