We present a 71-year-old man admitted to the intensive care unit with severe hypokalemia after ingesting licorice-containing confectionary over 6 weeks. Excess consumption of licorice with its active metabolite glycyrrhizic acid may precipitate pseudohyperaldosteronism with life-threatening hypokalemia. Public awareness and measures such as warning labels are needed to warn against excessive consumption.
View Article and Find Full Text PDFBackground: Initial ED assessment can use early warning scores to identify and prioritise patients who need time-critical treatment. We aimed to determine the accuracy of the National Early Warning Score version 2 (NEWS2) for predicting the need for time-critical treatment.
Methods: We undertook a single-centre retrospective observational cohort study.
Introduction: Smooth pursuit eye movements may be affected by head impacts. The EyeGuide Focus system is a simple, portable, test of visual tracking. This study investigated the diagnostic accuracy of EyeGuide measurements for detection of concussion during elite Rugby matches.
View Article and Find Full Text PDFBiopharmaceuticals are the fastest-growing class of drugs in the healthcare industry, but their global reach is severely limited by their propensity for rapid aggregation. Currently, surfactant excipients such as polysorbates and poloxamers are used to prevent protein aggregation, which significantly extends shelf-life. Unfortunately, these excipients are themselves unstable, oxidizing rapidly into 100s of distinct compounds, some of which cause severe adverse events in patients.
View Article and Find Full Text PDFObjectives: To evaluate if the tackler correctly adhering, or not, to four different instructions of legal front-on one-on-one torso tackles altered the tackler and/or ball carrier peak inertial head kinematics.
Design: Controlled laboratory study.
Methods: Fifteen rugby-code players measured with three-dimensional optoelectronic motion capture performed two tackle instructions from the Australian National Rugby League coaching manual on under (Dominant National Rugby League) and over (Smother National Rugby League) the ball tackles, and two novel variants of these (under, Dominant, Torso Stick; over, Smother, Pop, Lock).