Reported Side Effects and Adherence of Daily HIV Pre-Exposure Prophylaxis Users in Ontario, Canada: An Analysis of the Ontario Pre-Exposure Prophylaxis Cohort Study.

Side effects are a common concern of current and potential HIV pre-exposure prophylaxis (PrEP) users, potentially leading to missed doses. We examined the relationship between reported side effects and adherence in the Ontario PrEP Cohort Study (ON-PrEP). In total, 600 predominantly gay (87.

HIV pre-exposure prophylaxis and opportunities for vaccination against hepatitis A virus, hepatitis B virus and human papillomavirus: an analysis of the Ontario PrEP cohort study.

Objectives: Populations who seek HIV pre-exposure prophylaxis (PrEP) are disproportionately affected by hepatitis A virus (HAV), hepatitis B virus (HBV) and human papillomavirus (HPV). We examined immunity/vaccination against these infections among participants in the Ontario PrEP cohort study (ON-PrEP).

Methods: ON-PrEP is a prospective cohort of HIV-negative PrEP users from 10 Ontario clinics.

HIV self-testing enabled access to testing for Black persons: The GetaKit study.

In Ontario, new HIV diagnoses continue to affect gay, bisexual, and other men who have sex with men (gbMSM) and persons of African, Caribbean, or Black (ACB) ethnicities. Because treatment and suppressed viral loads flow from diagnosis, testing is key. We sought to determine the outcomes of online ordering and mail-out of free at-home HIV self-testing in Ontario, Canada.

H/D exchange under mild conditions in arenes and unactivated alkanes with CD and DO using rigid, electron-rich iridium PCP pincer complexes.

The synthesis and characterization of an iridium polyhydride complex () supported by an electron-rich PCP framework is described. This complex readily loses molecular hydrogen allowing for rapid room temperature hydrogen isotope exchange (HIE) at the hydridic positions and the α-C-H site of the ligand with deuterated solvents such as benzene-d, toluene-d and THF-d. The removal of 1-2 equivalents of molecular H forms unsaturated iridium carbene trihydride () or monohydride () compounds that are able to create further unsaturation by reversibly transferring a hydride to the ligand carbene carbon.

Supermetal: SbF-mediated methane oxidation occurs by C-H activation and isobutane oxidation occurs by hydride transfer.

SbF is generally assumed to oxidize methane through a methanium-to-methyl cation mechanism. However, experimentally no H is observed, and the mechanism of methane oxidation has remained unsolved for several decades. To solve this problem, density functional theory calculations with multiple chemical models (mononuclear and dinuclear) were used to examine methane oxidation by SbF in the presence of CO leading to the methyl acylium cation ([CHCO]).