Publications by authors named "G C Davis"
Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a "2-hit" model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF.
View Article and Find Full Text PDFObjective: To investigate barriers to leisure-time physical activity (LTPA) for physically active people with spinal cord injury (SCI).
Design: Prospective cross-sectional.
Setting: General community.
Background: Assessing proficiency in the initial management of a traumatically injured patient is challenging. Previously developed scoring tools frequently looked to evaluate single domains of a trauma leader or team's performance. An updated multi-domain scoring tool is needed to evaluate individual and group performance in the initial phases of trauma resuscitation.
View Article and Find Full Text PDFImportance: Clinical trials have demonstrated high vaccine efficacy (VE) against lower respiratory tract disease (LRTD) but enrolled a smaller proportion of persons aged 75 years or older and those with comorbidities than seen in highest-risk populations in clinical practice settings. Additionally, VE against respiratory syncytial virus (RSV)-related hospitalizations and emergency department (ED) visits is not yet fully described.
Objective: To estimate Respiratory Syncytial Virus Prefusion F (RSVpreF) effectiveness in older adults.