Tibial Components Placed in Constitutional Varus Alignment in Primary Total Knee Arthroplasty: A 5-Year Survivorship Analysis.

Introduction: Placing tibial components in varus alignment has been controversial due to concerns of loosening and subsequent revision. The purpose of this study was to compare five-year survivorship of tibial components placed in three degrees or greater of varus alignment versus neutral mechanical alignment (nMA).

Methods: This was a retrospective matched cohort study of 530 patients with 265 patients who underwent primary robotic-assisted total knee arthroplasty (TKA) with tibial components intentionally placed in varus matched to a control group of 265 patients who underwent TKA using manual instrumentation with tibial components placed in nMA.

Complete coding sequence of the Lumpy skin disease virus collected from cattle in Central Java, Indonesia, 2022.

We reported the complete coding sequence of a Lumpy skin disease virus (LSDV) isolated from cattle in Central Java, Indonesia, in 2022. The nucleotide sequence of the virus was most closely related to LSDV strains belonging to clade 2.5, which has been reported in East and Southeast Asia from 2019 to 2021.

Detection of mpox and other orthopoxviruses using a lateral flow device as a point-of-care diagnostic.

In 2022, the World Health Organization declared the worldwide outbreak of mpox to be a public health emergency of international concern. The causative monkeypox virus (MPXV) belonged to clade IIb and is transmitted through sexual contact with a low case fatality rate (0.1%), which, together with under-detection, all contributed to a rapid global spread particularly within the MSM (men who have sex with men) community.

Human-correlated genetic models identify precision therapy for liver cancer.

Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is a leading cause of cancer-related mortality worldwide. HCC occurs typically from a background of chronic liver disease, caused by a spectrum of predisposing conditions. Tumour development is driven by the expansion of clones that accumulate progressive driver mutations, with hepatocytes the most likely cell of origin.