Loss of cysteine 584 impairs the storage and release, but not the synthesis of von Willebrand factor.

Cysteines play a key part in von Willebrand factor (VWF) dimerisation and polymerisation, and their loss may severely affect VWF structure and function. We report on three patients with type 3 von Willebrand disease carrying the new c.1751G>T missense mutation that induces the substitution of cysteine 584 by phenylalanine (C584F), and the deletion of seven nucleotides in exon 7 (c.

The efficacy, safety and tolerance of ceftazidime for the treatment of bacterial infections in the elderly.

An open multicentre trial to study the efficacy and safety of ceftazidime in elderly patients has been conducted in four geriatric units on 135 subjects suffering from urinary-tract or respiratory-tract infections. Sixty-two patients were cured (45.9%), and 60 improved (44.

[Syphilitic pleuritis. Description of a clinical case].

A rare case of luetic pleurisy diagnosed in a patient with tertiary syphilis, when the aetiological agent was discovered in the pleuritic exudate is described. The spirochaetes, first revealed by dark field microscopy, were studied further under the electron microscope, using negative colouring and fine sections.