Publications by authors named "G C Cannon"
Objective: Determine whether pollutants such as fire smoke-related particulate matter smaller than 2.5 microns (PM) are associated with incident rheumatoid arthritis (RA) and RA-associated interstitial lung disease (RA-ILD).
Methods: This case-control study used Veterans Affairs data 10/1/2009-12/31/2018.
Background: Uncertainty exists regarding patient outcomes when using TNF inhibitors versus other biological and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis-associated interstitial lung disease (ILD). We compared survival and respiratory hospitalisation outcomes following initiation of TNF-inhibitor or non-TNF inhibitor biological or targeted synthetic DMARDs for treatment of rheumatoid arthritis-associated ILD.
Methods: We did a retrospective, active-comparator, new-user, observational cohort study with propensity score matching following the target trial emulation framework using US Department of Veterans Affairs (VA) electronic and administrative health records.
Article Synopsis
- - The Veterans Affairs (VA) system plays a key role in researching rheumatoid arthritis (RA) due to its extensive resources and reach within the U.S. healthcare system.
- - The VA Rheumatoid Arthritis Registry (VARA) features over 3,600 participants from 19 medical centers, providing rich longitudinal clinical data and biological samples, enhancing research capabilities.
- - With strong connections to various internal and external databases, VARA is well-positioned to tackle significant RA-related research questions in the future.
Objective: Investigate the association between the MUC5B rs35705950 promoter variant and survival in RA-associated interstitial lung disease (RA-ILD).
Methods: We studied participants in the Veteran Affairs Rheumatoid Arthritis (VARA) registry with validated ILD diagnoses. Participants were followed until death or end of study period.