Publications by authors named "G C Camatta"
Article Synopsis
- Identifying biomarkers for COVID-19 outcomes is essential for better managing high-risk patients and improving survival chances, particularly through early antiviral medication administration.
- A study involving 297 COVID-19 patients in Belo Horizonte, Brazil, explored the relationship between hematological parameters and disease severity using statistical analysis and machine learning.
- Findings indicate that monocyte percentage and granulocyte-to-lymphocyte ratio can effectively predict hospitalization risk, making these simple blood test parameters valuable tools for managing treatment in various healthcare settings.
Risk factors for the development of severe COVID-19 include several comorbidities, but age was the most striking one since elderly people were disproportionately affected by SARS-CoV-2 infection. Among the reasons for this markedly unfavorable response in the elderly, immunosenescence and inflammaging appear as major drivers of this outcome. A finding that was also notable was that hospitalized patients with severe COVID-19 have an accumulation of senescent T cells, suggesting that immunosenescence may be aggravated by SARS-CoV-2 infection.
View Article and Find Full Text PDFLiving in endemic area for infectious diseases accelerates epigenetic age.
Mech Ageing Dev
October 2022
Inflammaging is a low-grade inflammatory state generated by the aging process that can contribute to frailty and age-related diseases in the elderly. However, it can have distinct effects in the elderly living in endemic areas for infectious diseases. An increased inflammatory response may confer protection against infectious agents in these areas, although this advantage can cause accelerating epigenetic aging.
View Article and Find Full Text PDFImmunosenescence is marked by a systemic process named inflammaging along with a series of defects in the immunological activity that results in poor responses to infectious agents and to vaccination. Inflammaging, a state of low-grade chronic inflammation, usually leads to chronic inflammatory diseases and frailty in the elderly. However, some elderly escape from frailty and reach advanced age free of the consequences of inflammaging.
View Article and Find Full Text PDFObjective: To evaluate the percentage of body fat (% BF) in adolescents with PKU and to relate it to protein consumption, physical activity level, body mass index (BMI), sexual maturity and metabolic control.
Method: This is a cross-sectional study conducted with 94 adolescents between 10 and 20 years of age, with early diagnosis and continuous treatment. Bioimpedance, weight measurements, height and BMI calculation were performed.