Publications by authors named "G C Budd"
Purpose: While MEK inhibitors demonstrated activity in metastatic triple negative breast cancer (mTNBC) preclinical studies, preclinical, and clinical studies implicate rapid development of resistance limiting clinical benefit. The purpose of this study was to determine response rate for Trametinib alone and in combination with Uprosertib in patients with mTNBC previously treated with chemotherapy.
Methods: This was an open-label, two-part, phase II, single-arm, multicenter study.
Background: Spiders evolved different types of eyes, a pair of primary eyes that are usually forward pointing, and three pairs of secondary eyes that are typically situated more posterior and lateral on the spider's head. The best understanding of arthropod eye development comes from the vinegar fly Drosophila melanogaster, the main arthropod model organism, that also evolved different types of eyes, the larval eyes and the ocelli and compound eyes of the imago. The gene regulatory networks that underlie eye development in this species are well investigated revealing a conserved core network, but also show several differences between the different types of eyes.
View Article and Find Full Text PDFPurpose: ASCO/College of American Pathologists guidelines recommend reporting estrogen receptor (ER) and progesterone receptor (PgR) as positive with (1%-100%) staining. Statistically standardized quantitated positivity could indicate differential associations of positivity with breast cancer outcomes.
Methods: MA.
Pre-treatment amino acids and risk of paclitaxel-induced peripheral neuropathy in SWOG S0221.
Cancer Chemother Pharmacol
August 2024
Article Synopsis
- - The study examined the relationship between pre-treatment blood levels of amino acids and the occurrence and severity of chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer patients treated with paclitaxel.
- - While histidine levels were found not to be linked to the incidence of CIPN, some associations were noted between higher concentrations of glutamate, phenylalanine, tyrosine, and valine with increased CIPN severity, although these were not significant after further adjustments.
- - Overall, the findings suggest that amino acid concentrations are not strong predictors of CIPN severity, indicating a need for future research to explore other potential biomarkers.
Background: The common house spider Parasteatoda tepidariorum represents an emerging new model organism of arthropod evolutionary and developmental (EvoDevo) studies. Recent technical advances have resulted in the first single-cell sequencing (SCS) data on this species allowing deeper insights to be gained into its early development, but mid-to-late stage embryos were not included in these pioneering studies.
Results: Therefore, we performed SCS on mid-to-late stage embryos of Parasteatoda and characterized resulting cell clusters by means of in-silico analysis (comparison of key markers of each cluster with previously published information on these genes).