Publications by authors named "G C Bruijntjes-Rozier"
1. In order to study the potential beneficial effects of a vegan diet, a cross-sectional study was performed and several biomarkers of chemoprevention were measured in a population of female 'living food' eaters ('vegans'; n = 20) vs matched omnivorous controls (n = 20). 2.
View Article and Find Full Text PDF1. In order to study the antigenotoxic potential of eugenol in humans, ten healthy non-smoking males ingested a daily amount of 150 mg eugenol or the placebo for seven consecutive days. After a washout period of one week, groups ingesting eugenol or the placebo were crossed and received the other treatment for seven consecutive days.
View Article and Find Full Text PDFThe influence of in vivo treatment with eugenol on established mutagens was studied to determine whether eugenol has antigenotoxic potential. The effects of eugenol in rats was investigated in the unscheduled DNA synthesis (UDS) assay with established mutagens and the Salmonella typhimurium mutagenicity assay. In addition, the effect of in vivo treatment with eugenol on benzo[a]pyrene (B[a]P)-induced genotoxicity in human hepatoma cell line Hep G2 was investigated in the single-cell gel electrophoresis assay.
View Article and Find Full Text PDFModified suspension Ames test for testing proteinaceous substances: an initial step.
Food Chem Toxicol
December 1994
Article Synopsis
- The basic Ames test is a key method to distinguish between mutagens and non-mutagens but can produce false positives with protein-based substances due to growth factors like histidine.
- The 'suspension variant' of the Ames test was proposed to mitigate these false positives by using rich growth conditions to overpower any growth-promoting substances in the test.
- Key modifications to this new test included plating bacteria that had regrown overnight without histidine and nutrient broth, suggesting a promising direction for refining the Ames test specifically for proteinaceous materials.