Publications by authors named "G C Baldwin"

Purpose Of Review: Intimate partner violence (IPV) is a leading cause of death and disability across the world. We sought to investigate the prevalence and clinical presentation of ocular injuries in IPV.

Recent Findings: Literature review revealed 16 published studies that evaluated ocular injuries in IPV, of which the study types included 9 retrospective studies, 2 prospective, 1 review, 1 invited commentary, 2 case reports, and 1 population-based cross-sectional survey.

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The choice of organism to host a genetic circuit, the chassis, is often defaulted to model organisms due to their amenability. The chassis-design space has therefore remained underexplored as an engineering variable. In this work, we explored the design space of a genetic toggle switch through variations in nine ribosome binding site compositions and three host contexts, creating 27 circuit variants.

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Article Synopsis
  • This study explores the relationships between OCT biomarkers and contrast sensitivity in eyes diagnosed with intermediate age-related macular degeneration (iAMD), aiming to improve understanding of disease progression.
  • A total of 205 eyes from 134 patients were analyzed; findings reveal that higher retinal pigment epithelium volume and intraretinal hyperreflective foci correlate with poorer contrast sensitivity measures.
  • Over a follow-up period, approximately 43% of eyes progressed to late-stage AMD, indicating the potential clinical significance of the identified biomarkers in predicting progression.
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Arsenic trioxide (ATO) has been shown to inhibit pancreatic cancer (PC) cell growth and to promote the inhibitory effects of gemcitabine (Gem) on PC . However, the high toxicity of ATO associated with the required high doses and indiscriminate targeting has limited its clinical application. This study aimed to determine whether coupling arsenic to a tumor homing peptide would increase the inhibitory potency against PC cells.

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