Publications by authors named "G C B Lacerda"
Adaptive Compensatory Neurophysiological Biomarkers of Motor Recovery Post-Stroke: Electroencephalography and Transcranial Magnetic Stimulation Insights from the DEFINE Cohort Study.
Brain Sci
December 2024
Objective: This study aimed to explore longitudinal relationships between neurophysiological biomarkers and upper limb motor function recovery in stroke patients, focusing on electroencephalography (EEG) and transcranial magnetic stimulation (TMS) metrics.
Methods: This longitudinal cohort study analyzed neurophysiological, clinical, and demographic data from 102 stroke patients enrolled in the DEFINE cohort. We investigated the associations between baseline and post-intervention changes in the EEG theta/alpha ratio (TAR) and TMS metrics with upper limb motor functionality, assessed using the outcomes of five tests: the Fugl-Meyer Assessment (FMA), Handgrip Strength Test (HST), Pinch Strength Test (PST), Finger Tapping Test (FTT), and Nine-Hole Peg Test (9HPT).
Background: Spinal cord injury (SCI) affects approximately 250,000 to 500,000 individuals annually. Current therapeutic interventions predominantly focus on mitigating the impact of physical and neurological impairments, with limited functional recovery observed in many patients. Electroencephalogram (EEG) oscillations have been investigated in this context of rehabilitation to identify effective markers for optimizing rehabilitation treatments.
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- This study looks at how body mass index (BMI) impacts the relationship between sensory pain testing and clinical symptoms in fibromyalgia syndrome (FMS).
- It finds that higher BMI, particularly being overweight or obese, affects how pain response mechanisms relate to symptoms like depression, and this influence is not seen in normal-weight individuals.
- The research emphasizes the importance of considering BMI in FMS treatment strategies, suggesting that high BMI disrupts the body’s ability to manage pain, which can worsen overall health outcomes.
Article Synopsis
- Many people, including those with mental health issues, use Complementary and Alternative Medicine (CAM) but often don’t tell their doctors.
- Using CAM alongside regular medicines can change how well mental health treatments work.
- Doctors need to know about herbal medicines and ask patients about their use to give the best care, and more research is needed in this area.
Article Synopsis
- - The study investigates the outcomes of therapeutic hypothermia (TH) in newborns with hypoxic-ischemic encephalopathy (HIE) at a hospital in Rio de Janeiro, focusing on the frequency of epilepsy, neurological issues, and developmental delays at 12 months of age.
- - Findings revealed that 18.2% of patients experienced epilepsy, 40.9% had altered neurological exams, and 36.4% showed neurodevelopmental delays, confirming that TH does not eliminate adverse outcomes.
- - The research highlights challenges like limited access to imaging exams and a significant loss to follow-up, suggesting the need for better resource allocation and early interventions to improve patient outcomes.