Use of the levonorgestrel-releasing intrauterine system in breast cancer patients.

Objective: To study the recurrence of breast cancer among patients who were using the levonorgestrel-releasing intrauterine system (LNG IUS).

Design: A retrospective, controlled cohort analysis.

Setting: Six Belgian hospitals.

Iron supplementation during pregnancy.

As pregnancy proceeds most women show hematologic changes suggesting iron deficiency. In this study iron dynamics are investigated by determining concentrations of hemoglobin, serum ferritin and serum transferrin in two groups of pregnant women. One group did not receive iron, the other received 105 mg iron/day.

Effects of zopiclone as compared to flurazepam on sleep in women over 40 years of age.

Zopiclone is a new nonbenzodiazepine hypnotic, the recommended dose of which is 7.5 mg. It was compared to flurazepam 30 mg in a sleep laboratory study.

Effect of oestriol on the oscillation of circulating gonadotrophins in post-menopausal women during sleep.

The effect of oestriol on the rapid oscillation of circulating FSH and LH levels during sleep was investigated by administering oestriol (E3: 2 mg/day) orally for 3 mth to 3 healthy post-menopausal women who experienced frequent hot flushes. Before treatment and at the end of the third mth of treatment, blood samples were drawn the length of sleep, and serum FSH and LH level were measured by radioimmunoassay. Fluctuations of serum FSH and LH levels were recorded and the pulses were defined as a 20% increase of hormone concentration over nadir.