Publications by authors named "G Bulli"
Article Synopsis
- Ferroptosis is a key form of cell death linked to various diseases, characterized by excessive peroxidation of fatty acids in cell membranes, which causes the cell to rupture.
- This process is influenced by iron and redox balance within cells but can also be targeted for pharmacological treatments, making ferroptosis-related proteins potential candidates for new therapies.
- A research consortium in Germany, along with leading experts, aims to review the mechanisms, significance, and methodologies related to ferroptosis to promote further research and potential new treatments for diseases affected by this process.
Mitochondria account for essential cellular pathways, from ATP production to nucleotide metabolism, and their deficits lead to neurological disorders and contribute to the onset of age-related diseases. Direct neuronal reprogramming aims at replacing neurons lost in such conditions, but very little is known about the impact of mitochondrial dysfunction on the direct reprogramming of human cells. Here, we explore the effects of mitochondrial dysfunction on the neuronal reprogramming of induced pluripotent stem cell (iPSC)-derived astrocytes carrying mutations in the NDUFS4 gene, important for Complex I and associated with Leigh syndrome.
View Article and Find Full Text PDFEvidence on the effectiveness of SARS-CoV-2 vaccines in nursing home (NHs) residents is limited. We examined the impact of the BNT162b2 mRNA SARS-CoV-2 vaccine on the course of the epidemic in NHs in the Florence Health District, Italy, before and after vaccination. Moreover, we assessed survival and hospitalization by vaccination status in SARS-CoV-2-positive cases occurring during the post-vaccination period.
View Article and Find Full Text PDFBackground: Nursing home (NH) residents have been dramatically affected by COVID-19, with extremely high rates of hospitalization and mortality.
Aims: To describe the features and impact of an assistance model involving an intermediate care mobile medical specialist team (GIROT, Gruppo Intervento Rapido Ospedale Territorio) aimed at delivering "hospital-at-nursing home" care to NH residents with COVID-19 in Florence, Italy.
Methods: The GIROT activity was set-up during the first wave of the pandemic (W1, March-April 2020) and became a structured healthcare model during the second (W2, October 2020-January 2021).