Inhibitor-of-differentiation 2 (Id2) belongs to a family of transcriptional modulators that are characterized by a helix loop helix region but lack the basic amino acid domain. During development, Id2 antagonizes differentiation mediated by the retinoblastoma protein, probably by scavenging downstream E-box basic helix-loop-helix proteins. Here, using differential display RT-PCR, we identify Id2 as an induced gene during serum and potassium deprivation-induced apoptosis of cerebellar granule neurons.
View Article and Find Full Text PDFObjective: To determine whether homeopathic Arnica can reduce postoperative haematomas in venous surgery.
Design: Randomized, prospective, multicentric, double-blind placebo-controlled trial.
Participants: 130 consecutive patients undergoing saphenous stripping (204 legs), hospitalized in a clinic.
Rev Med Suisse Romande
October 1998
alpha-SNAP [soluble N-ethylmaleimide-sensitive fusion protein (NSF)-attachment protein] is required for fusion of transport vesicles with their target membrane. In this study, we have examined the membrane-binding properties of alpha-SNAP. We have found that in several tissues a much larger amount of alpha-SNAP per unit weight of protein is bound to membranes than is free in the cytosol.
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