Publications by authors named "G Bottiglieri"
Background: Few data are available on polymer-free drug-eluting stents in patients undergoing percutaneous coronary intervention (PCI).
Aims: We aimed to determine the efficacy and safety of a polymer-free amphilimus-eluting stent (AES), using a reservoir-based technology for drug delivery, compared with a biodegradable-polymer everolimus-eluting stent (EES).
Methods: This was a randomised, investigator-initiated, assessor-blind, non-inferiority trial conducted at 14 hospitals in Italy (ClinicalTrials.
Rationale and design of the PARTHENOPE trial: A two-by-two factorial comparison of polymer-free vs biodegradable-polymer drug-eluting stents and personalized vs standard duration of dual antiplatelet therapy in all-comers undergoing PCI.
Am Heart J
November 2023
Article Synopsis
- The PARTHENOPE trial investigates the clinical performance of two types of drug-eluting stents (Cre8 and SYNERGY) in patients undergoing percutaneous coronary intervention (PCI), aiming to understand the best duration for dual antiplatelet therapy (DAPT).
- The study randomizes 2,107 patients to either personalized or standard DAPT durations based on their DAPT score, which takes into account the risk of bleeding and ischemia.
- The trial's primary goal is to show that both stents are equally effective in preventing major cardiovascular events after 12 months, while also assessing whether personalized DAPT is more beneficial than the standard 12-month approach.
Considering the consistent reduction in battery range due to the operation of the Heating Ventilation and Air Conditioning (HVAC) system, this study deals with the CO measurement inside the cabin of an electric crane and aims to reduce the energy consumption through the control of the air recirculation. A control strategy was defined and tested through an experimental set-up where the presence of a driver was simulated as a source of CO. The cabin was placed inside a climatic wind tunnel and the benefits of this control strategy on the HVAC system energy consumption were assessed, both in the heating and the cooling modes.
View Article and Find Full Text PDFExcimer Laser Coronary Atherectomy (ELCA) is a well-established therapy that emerged for the treatment of peripheral vascular atherosclerosis in the late 1980s, at a time when catheters and materials were rudimentary and associated with the most serious complications. Refinements in catheter technology and the introduction of improved laser techniques have led to their effective use for the treatment of a wide spectrum of complex coronary lesions, such as thrombotic lesions, severe calcific lesions, non-crossable or non-expandable lesions, chronic occlusions, and stent under-expansion. The gradual introduction of high-energy strategies combined with the contrast infusion technique has enabled us to treat an increasing number of complex cases with a low rate of periprocedural complications.
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