Publications by authors named "G Bonomo"
: Elastic image fusion (EIF) using an intraoperative CT (iCT) scan may enhance neuronavigation accuracy and compensate for brain shift. : To evaluate the safety and reliability of the EIF algorithm (Virtual iMRI Cranial 4.5, Brainlab AG, Munich Germany, for the identification of residual tumour in glioblastoma surgery.
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- The review examines the role of local antimicrobial protection in one-stage cemented and cementless hip revision surgeries, analyzing twelve studies on cemented procedures and seventeen studies on cementless procedures with at least two years of follow-up data.
- Results indicate that 83.3% of patients treated with cemented procedures had no infection recurrence, while those treated without antibiotic-loaded cement showed a higher infection control rate of 95.9%.
- For cementless procedures, 90.0% of patients remained infection-free on average, but no studies directly compared the effectiveness of local antibacterial protection, leading to inconclusive results regarding its role in surgery despite being safe and widely used.
Background: CDKL5 Deficiency Disorder (CDD) is a rare developmental and epileptic encephalopathy characterized by dominant X-linked inheritance and early infantile onset. To date, more than 300 pathogenic variants of the CDKL5 gene have been reported with different phenotypes. As a rare genetic disease, data on CDD are still limited, making the diagnostic and therapeutic process very challenging.
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- - The study explores the connection between Ollier disease (OD), acute myeloid leukemia (AML), and brain glioma (BG), which are distinct types of tumors but can occur in the same patient, and aims to find shared molecular pathways for potential treatment.
- - A systematic literature review was conducted, revealing that thirty-three patients with both OD and BG were identified in previous studies, and only one documented case linked OD with AML—our case included all three diseases.
- - The IDH R132H mutation was identified as a common genetic alteration in all three types of tumors, suggesting that targeted therapies using IDH1 inhibitors could provide new treatment options, although further research with larger groups is needed to validate these findings.
Objective: To conduct a comprehensive comparison of microwave ablation (MWA) vs radiofrequency ablation (RFA) outcomes in the treatment of small renal masses (SRMs), specifically: TRIFECTA ([i] complete ablation, [ii] absence of Clavien-Dindo Grade ≥III complications, and [iii] absence of ≥30% decrease in estimated glomerular filtration rate) achievement, operative time (OT), and local recurrence rate (LRR).
Patients And Methods: We retrospectively analysed 531 patients with SRMs (clinical T1a-b) treated with MWA or RFA at a single centre (2008-2022). First, multivariable logistic regression models were used for testing TRIFECTA achievement.