Basic Science and Pathogenesis.

Background: Tau phosphorylated at threonine-217 (tau), which can be measured in plasma and CSF using antibodies, is one of the most promising early biomarkers for Alzheimer's disease (AD). Little was known, however, about the cellular and subcellular distributions of tau, how those levels change during disease progression, the factor(s) that provoke tau accumulation, or functional consequences of tau phosphorylation at T217. This study addressed all of those issues.

Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP knock-in mouse model of Alzheimer's disease.

Introduction: Reduced brain energy metabolism, mammalian target of rapamycin (mTOR) dysregulation, and extracellular amyloid beta (Aβ) oligomer (xcAβO) buildup are some well-known Alzheimer's disease (AD) features; how they promote neurodegeneration is poorly understood. We previously reported that xcAβOs inhibit nutrient-induced mitochondrial activity (NiMA) in cultured neurons. We now report NiMA disruption in vivo.

Dual career in sport and non-sport work: Exploring experiences of North American professional female ice hockey players.

Grounded in role strain theory, this study explored the dual career experiences of North American female ice hockey players who were also involved in full-time non-sporting work, focusing on factors that produced and reduced their role strain. We interviewed ten professional ice hockey players who held full-time non-sport jobs at the time of their interview. Our reflexive thematic analysis revealed that the multitude of factors leading to role strain among professional female working-athletes were notably significant, spanning societal expectations and environmental complexities.