Publications by authors named "G Bianchi Porro"
A Retrospective, Nationwide, Multicenter Study on Diagnosis and Treatment Outcome of Pediatric Optic Pathway/Hypothalamic Gliomas Including Analysis of Risk Factors for Progression After Systemic Anticancer Therapy.
Cancers (Basel)
February 2025
The current standard therapy for pediatric optic pathway/hypothalamic glioma (OPHG) is systemic anticancer therapy (SAT) over surgery and radiotherapy. Nevertheless, recurrent radiological or clinical tumor progression after SAT forms a considerable challenge. Sporadic OPHGs are considered to have a higher tendency toward progression after first-line systemic anticancer therapy (SAT) compared to neurofibromatosis type-1-associated (NF1) OPHGs.
View Article and Find Full Text PDFPurpose: To examine long-term visual impairment and visual field examination (VF) after diverse treatments for paediatric optic pathway glioma (OPG), and to determine prognostic factors for long-term severe visual impairment or blindness.
Methods: A nationwide retrospective cohort study (1995-2018) was performed on paediatric OPGs that received various (successive) therapies. The analysis of severe VI or blindness was represented by the outcome of both BCVA and VF testing.
Treatment of isolated pediatric optic nerve glioma: A nationwide retrospective cohort study and systematic literature review on visual and radiological outcome.
Pediatr Blood Cancer
December 2024
Article Synopsis
- Progressive isolated optic nerve glioma (ONG) in children is a rare condition with no standard treatment consensus, and a study was conducted to compare the effectiveness of different treatment methods.
- The study involved 21 ONGs where systemic anticancer therapy (SAT) led to visual improvements in a significant number of cases, while surgery often resulted in worsening vision, and radiotherapy had mixed effects, including a potential increase in tumor volume shortly after treatment.
- The findings suggest that SAT is the preferred treatment for preserving vision, while surgery may help alleviate other symptoms in blind patients, but radiotherapy poses risks and needs careful evaluation before use.
Diagnostic performance of pupil perimetry in detecting hemianopia under standard and virtual reality viewing conditions.
Graefes Arch Clin Exp Ophthalmol
February 2025
Purpose: To determine the diagnostic performance and reliability of two pupil perimetry (PP) methods in homonymous hemianopia.
Methods: This cross-sectional monocenter cohort study performed gaze-contingent flicker PP (gcFPP) and a virtual reality version of gcFPP (VRgcFPP) twice on separate occasions in all patients suffering from homonymous hemianopia due to neurological impairment. The main outcomes were (1) test accuracy and (2) test-retest reliability: (1) was measured through area under the receiver operating characteristics curve (AUC) calculation of (VR)gcFPP results with comparators being SAP and healthy controls, respectively; (2) was evaluated by comparing tests 1 and 2 of both methods within patients.