Publications by authors named "G Bernardini"
Missing values arise routinely in real-world sequential (string) datasets due to: (1) imprecise data measurements; (2) flexible sequence modeling, such as binding profiles of molecular sequences; or (3) the existence of confidential information in a dataset which has been deleted deliberately for privacy protection. In order to analyze such datasets, it is often important to replace each missing value, with one or more letters, in an efficient and effective way. Here we formalize this task as a combinatorial optimization problem: the set of constraints includes the of the missing value (i.
View Article and Find Full Text PDFTo contrast the rapid spread of antibiotic resistance in bacteria, new alternative therapeutic options are urgently needed. The use of nanoparticles as carriers for clinically relevant antibiotics represents a promising solution to potentiate their efficacy. In this study, we used larvae for the first time as an animal model for testing a nanoconjugated glycopeptide antibiotic (teicoplanin) against infection.
View Article and Find Full Text PDFArticle Synopsis
- Lesch-Nyhan disease (LND) is a rare genetic disorder caused by a deficiency in the HPRT enzyme, leading to motor disabilities, cognitive deficits, and self-harm behaviors.
- Recent advances in stem cell research, particularly with human pluripotent stem cells, provide new methods to study LND's underlying neurological mechanisms.
- This review evaluates current stem cell models for LND, their potential for uncovering key pathological events, and discusses challenges and future directions for improving research using induced pluripotent stem cells.
Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages.
J Biomed Sci
November 2024
Background: Cell therapy has emerged as a revolutionary tool to repair damaged tissues by restoration of an adequate vasculature. Dental Pulp stem cells (DPSC), due to their easy biological access, ex vivo properties, and ability to support angiogenesis have been largely explored in regenerative medicine.
Methods: Here, we tested the capability of Dental Pulp Stem Cell-Conditioned medium (DPSC-CM), produced in normoxic (DPSC-CM Normox) or hypoxic (DPSC-CM Hypox) conditions, to support angiogenesis via their soluble factors.