Publications by authors named "G Berlakovich"

Background: Corroborating evidence for use of hypothermic oxygenated machine perfusion (HOPE) prior to orthotopic liver transplantation (OLT) suggests a beneficial effect in regards to biliary complications. Here, we aim to evaluate whether perfusion via portal vein alone (sHOPE) or via additional perfusion of the hepatic artery (dHOPE) have diverging impact on outcomes after OLT when compared to use of static cold storage (SCS).

Methods: Consecutive patients undergoing OLT at Medical University of Vienna (2018 to 2023) were retrospectively analyzed.

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Article Synopsis
  • Scientists are studying how to tell if a donated liver is healthy enough to use for transplant by looking at special markers during a process called HOPE.
  • They collected samples from livers in 10 different centers across 7 countries and found that the levels of a marker called FMN can help predict if the liver will work well after being transplanted.
  • The study showed that FMN is better at predicting liver problems compared to older methods, making it a promising tool for doctors to decide which livers are suitable for transplant.
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Induction therapy with depleting antibodies in the setting of liver transplantation (LT) is discussed controversially to this day. The rabbit antithymocyteglobulin (ATG) Thymoglobulin (rATG) was introduced as early as 1984 and was frequently used as a standard regime for induction therapy after LT. There are no public reports characterizing Grafalon (ATG-F), a novel ATG, as an induction agent after LT.

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Background: Induction of donor-specific tolerance is a promising approach to achieve long-term graft patency in transplantation with little to no maintenance immunosuppression. Changes to the recipient's T cell receptor (TCR) repertoire are understood to play a pivotal role in the establishment of a robust state of tolerance in chimerism-based transplantation protocols.

Methods: We investigated changes to the TCR repertoires of patients participating in an ongoing prospective, controlled, phase I/IIa trial designed to evaluate the safety and efficacy of combination cell therapy in living donor kidney transplantation.

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Article Synopsis
  • A new study evaluated long-term outcomes of liver transplants from donors treated with hypothermic oxygenated machine perfusion (HOPE) across 22 European centers, involving 1,202 transplant cases from 2012 to 2021.
  • The study showed high 1-, 3-, and 5-year death-censored graft survival rates for both donation after brain death (DBD) and donation after circulatory death (DCD), with low rates of primary non-function (PNF) and ischaemic cholangiopathy (IC).
  • The findings indicate that HOPE treatment effectively improves liver transplant outcomes, regardless of the donor's risk profile, and supports its incorporation into routine clinical practice.
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