Genetic Diagnostics in Routine Osteological Assessment of Adult Low Bone Mass Disorders.

Context: Many different inherited and acquired conditions can result in premature bone fragility/low bone mass disorders (LBMDs).

Objective: We aimed to elucidate the impact of genetic testing on differential diagnosis of adult LBMDs and at defining clinical criteria for predicting monogenic forms.

Methods: Four clinical centers broadly recruited a cohort of 394 unrelated adult women before menopause and men younger than 55 years with a bone mineral density (BMD) Z-score < -2.

The emergency department incidence of incidental intracranial aneurysm on computed tomography angiography (EPIC-ACT) study.

Background: Subarachnoid hemorrhage has been traditionally ruled-out in the emergency department (ED) through computed tomography (CT) followed by lumbar puncture if indicated. Mounting evidence suggests that non-contrast CT with CT angiography (CTA) can safely rule-out subarachnoid hemorrhage and obviate the need for lumbar puncture, but adoption of this approach is hindered by concerns of identifying incidental aneurysms. This study aims to estimate the incidence of incidental aneurysms identified on CTA head and neck in an ED population.