Publications by authors named "G Beck-Engeser"
Background: Frailty occurs at higher rates and younger ages among people with HIV (PWH) compared with the general population and is often attributed to chronic inflammation and subsequent immune exhaustion. We assessed how inflammatory biomarkers are associated with frailty among PWH.
Methods: The Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) cohort is comprised of adult PWH in care at 10 sites, and harmonizes demographic, clinical, and patient-reported outcomes (PRO) data.
Introduction: Patients with the acquired immunodeficiency syndrome (AIDS) have an increased prevalence and incidence of intermediate-stage age-related macular degeneration (AMD). Several elevated plasma inflammatory biomarkers are associated with increased incidence of intermediate-stage AMD in this population. We evaluated the association between AMD risk alleles and plasma inflammatory biomarker levels in persons with AIDS.
View Article and Find Full Text PDFPurpose: To evaluate associations of plasma levels of inflammatory biomarkers with age-related macular degeneration (AMD) and cataract in persons with AIDS.
Design: Nested case-control study (analysis 1) and nested cohort study (analysis 2).
Participants: Analysis 1: persons with AIDS and incident intermediate-stage AMD (n = 26) and controls without AMD matched for age, race/ethnicity, and gender (n = 49) from The Longitudinal Study of Ocular Complications of AIDS.
Article Synopsis
- A study of the neuropilin-1 (NRP-1) protein revealed it has a strong link to coronary plaque in people with HIV, as seen in the REPRIEVE trial's proteomics analysis.
- The association of NRP-1 with proteins involved in crucial biological processes like angiogenesis and immune response, as well as host factors (older age, male sex), indicates its importance in health outcomes.
- NRP-1 is linked to higher risks of various cancers and mortality, particularly related to type 2 myocardial infarction, highlighting its role in serious health issues faced by individuals with HIV.
Article Synopsis
- * Results show that recent EBV reactivation is significantly associated with symptoms like fatigue and neurocognitive dysfunction, while HIV infection is linked to increased neurocognitive issues, and past CMV infection appears to reduce the likelihood of neurocognitive symptoms.
- * These findings highlight the complex interactions between chronic viral infections and long COVID, suggesting that further research on viral impacts during the acute COVID-19 phase is necessary.