Changes in hematological and hematochemical parameters in lactating dairy sheep according to different pasture management and heat stress risk: A longitudinal study.

Sheep in Italy are exposed to heat stress (HS) for several months, increasing the risk of HS-related problems such as the decrease in growth, reproductive performance, milk quantity and quality and natural immunity. This study aimed to assess changes in hematological and biochemical parameters in dairy sheep from three different farms with varying pasture management: A (no water or shade), B (water but no shade), and C (both water and shade). From March to June, when HS risk is high, monthly blood samples (T1-T4) were collected from 20 sheep per farm (total n = 60).

Study of Microbiota Associated to Early Tumors Can Shed Light on Colon Carcinogenesis.

An increasingly important role for gut microbiota in the initiation and progression of colorectal cancer (CRC) has been described. Even in the early stages of transformation, i.e.

Gliotic Response and Reprogramming Potential of Human Müller Cell Line MIO-M1 Exposed to High Glucose and Glucose Fluctuations.

Retinal neurodegeneration (RN), an early marker of diabetic retinopathy (DR), is closely associated with Müller glia cells (MGs) in diabetic subjects. MGs play a pivotal role in maintaining retinal homeostasis, integrity, and metabolic support and respond to diabetic stress. In lower vertebrates, MGs have a strong regenerative response and can completely repair the retina after injuries.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Evaluation of 3D-Printed Feline Skull Models as Educational Tools for Radiographic Interpretation of Craniomaxillofacial Traumatic Injuries: A Randomized Trial.

Three-dimensional (3D)-printed models have been shown to improve medical students' understanding of anatomy and related fractures. The aim of this parallel-group randomized trial was to evaluate the impact of 3D-printed feline skulls, in addition to traditional teaching, on veterinary students' interpretation of skull radiographs. Students were randomly divided into two groups (2D, 3D) and underwent a pre-test consisting of multiple-choice questions.