Publications by authors named "G Battaglia"
Pharmacological Blockade of Group II Metabotropic Glutamate Receptors Reduces the Incidence of Brain Tumors Induced by Prenatal Exposure to N-ethyl-N-nitrosourea in Rats.
Curr Neuropharmacol
December 2024
Background: The study demonstrates that pharmacological blockade of type 3 metabotropic glutamate (mGlu3) receptors at the time of tumor induction significantly reduces the incidence of brain gliomas in rats. The overall survival of patients with high-grade brain gliomas is 14-20 months after current multimodal therapy, including surgery, radiotherapy, and adjuvant chemotherapy.
Objective: To demonstrate in this experimental model that pharmacological blockade of group II metabotropic glutamate receptors reduces the incidence of brain tumors induced by prenatal exposure to N- ethyl-N-nitrosourea (ENU) in rats.
Article Synopsis
- - Alternative splicing includes microexons in neuronal proteins, which are often linked to neurodevelopmental disorders, including autism spectrum disorder (ASD).
- - A specific 24-nucleotide microexon in the RNA-binding protein CPEB4, previously shown to be less included in individuals with ASD, plays a critical role in regulating gene expression linked to neurodevelopment.
- - The study finds that this microexon helps maintain the flexible regulation of CPEB4 during neuronal activation by preventing its aggregation, allowing it to switch from repressing to activating translation of genes.
The interaction between basic science epilepsy researchers and clinical epileptologists is a longstanding issue. Efforts to provide opportunities for a dialogue between preclinical and clinical epilepsy professionals are crucial to reduce the knowledge gap between them and improve the translational success of neurobiology-based research. The International League Against Epilepsy (ILAE) Research and Innovation Task Force circulated a survey to investigate the need for an update on new clinical epilepsy concepts within the basic science community.
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- This case report emphasizes the need for comprehensive testing methods, including video-EEG, MEG, and MRI, to accurately diagnose negative motor seizures (NMSs) and differentiate them from other conditions.
- The study presents a 62-year-old patient with drug-resistant focal epilepsy and NMSs, highlighting the importance of monitoring that indicated specific brain activity and muscular responses during seizures.
- Findings from the multimodal evaluations revealed an epileptic zone in the right opercular region, associated with brain abnormalities, thereby improving our understanding of NMSs and their underlying brain mechanisms.