Effects of Vaginal vs. Oral Progesterone Supplementation Before Embryo Transfer on Live Birth Rates and Levels: A Randomized Trial.

The increase in frozen embryo transfers is a consequence of advances in embryo vitrification and the implementation of genetic screening of embryos. There is debate over the best progesterone administration route in substituted cycles and the relationship between progesterone levels on embryo transfer day and reproductive outcomes. This trial aimed to compare the clinical results of different progesterone supplementation schedules before embryo transfer and assess the relationship between plasmatic progesterone levels on transfer day and clinical outcomes.

Intraovarian platelet-rich plasma injection and IVF outcomes in patients with poor ovarian response: a double-blind randomized controlled trial.

Study Question: Does platelet-rich plasma (PRP) intraovarian injection increase the number of retrieved oocytes in successive ovarian punctions among patients with poor ovarian reserve (POR)?

Summary Answer: The injection of PRP increases the number of retrieved oocytes without increasing the quality of developed blastocysts.

What Is Known Already: Management of women with reduced ovarian response to stimulation is one of the significant challenges in reproductive medicine. Recently, PRP treatment has been proposed as an adjunct in assisted reproduction technology, with controversial results.

Use of gonadotropins in ovarian stimulation in Spain: Delphi consensus.

Two-round Delphi study carried out in Spain. Three theme-based blocks were set out: 1) Patient profiles: therapeutic goal and parameters to be analysed according to POSEIDON patient profiles; 2) Ovarian stimulation protocols with antagonists: monotherapy (FSH) vs combined therapy (FSH + LH/HMG); 3) Safety and effectiveness of the devices. The antral follicle count and the anti-Müllerian hormone level were considered indicators that can be used to predict ovarian response.