Publications by authors named "G Barnes Bloom"
Article Synopsis
- Alterations in NADH and NADPH metabolism are linked to aging, cancer, and Alzheimer's Disease.
- Research shows that tau oligomers increase mitochondrial NADPH production through an enzyme called NADK2 in both human neurons and mouse brains.
- This increase in NADPH contributes to a harmful cycle that enhances the internalization of tau oligomers, leading to increased toxicity in neurons.
Introduction: Reduced brain energy metabolism, mammalian target of rapamycin (mTOR) dysregulation, and extracellular amyloid beta (Aβ) oligomer (xcAβO) buildup are some well-known Alzheimer's disease (AD) features; how they promote neurodegeneration is poorly understood. We previously reported that xcAβOs inhibit nutrient-induced mitochondrial activity (NiMA) in cultured neurons. We now report NiMA disruption in vivo.
View Article and Find Full Text PDFGrounded in role strain theory, this study explored the dual career experiences of North American female ice hockey players who were also involved in full-time non-sporting work, focusing on factors that produced and reduced their role strain. We interviewed ten professional ice hockey players who held full-time non-sport jobs at the time of their interview. Our reflexive thematic analysis revealed that the multitude of factors leading to role strain among professional female working-athletes were notably significant, spanning societal expectations and environmental complexities.
View Article and Find Full Text PDFObjective: To establish the pharmacokinetics of the cyclin-dependent kinase-9 inhibitor flavopiridol in equine middle carpal joints, using an extended-release poly lactic-co-glycolic acid (PLGA) microparticle formulation.
Animals: 4 healthy horses without evidence of forelimb lameness.
Methods: A 6-week longitudinal pharmacokinetic study was conducted in 2 phases (6 weeks each) in 4 healthy horses.