Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung.

Bacteremia, a leading cause of death, generally arises after bacteria establish infection in a particular tissue and transit to secondary sites. Studying dissemination from primary sites by solely measuring bacterial burdens does not capture the movement of individual clones. By barcoding Klebsiella pneumoniae, a leading cause of bacteremia, we track pathogen dissemination following pneumonia.

Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens.

Bacterial infections can induce exuberant immune responses that can damage host tissues. Previously, we demonstrated that systemic infection in mice causes tissue damage in the liver. This liver necrosis is associated with the expression of endogenous retroviruses, chromosomally integrated retroviruses that encode a reverse transcriptase.

Editorial Commentary: Losartan May Prevent Clinically Significant Postoperative Fibrosis, but Large Database Studies May Not Provide an Answer.

Losartan and other modulators of the renin-angiotensin system have been used for their antifibrotic effects by nonsurgeons for decades when suppression of maladaptive scar deposition is helpful, such as heart failure and chronic kidney disease. Only recently have orthopaedic surgeons begun to explore whether these medications might reduce or prevent postoperative joint stiffness. The relationship between orthopaedic surgeons and fibrosis is more complicated.

Synthesis and Redox Chemistry of CoE (E=P, As) Clusters.

The synthesis of the cluster complexes [(Cp'''Co)(μ,η:η:η-E)(μ-E)] (E=P (3), As (4)) starting from the anionic triple-decker complexes [K(18cr6)(dme)][(Cp'''Co)(μ,η:η-E)] (E=P (1), As (2)) by electrophilic quenching with the Co dimer [(Cp'''CoCl)] is reported. Both complexes show a distinct redox chemistry, which was first investigated by cyclic voltammetry. Subsequently, the monoanions [K(L)(sol)][(Cp'''Co)(μ,η:η:η-E)(μ-E)] (E=P, L=18cr6, sol=dme, n=2 (5), E=As, L=2,2,2-crypt, n=0 (6)), the monocations [(Cp'''Co)(μ,η:η:η-E)(μ-E)][FAl] (E=P (7), As (8)) and the dications [(Cp'''Co)(μ,η:η:η-E)][TEF] (E=P (9), As (10)) could be realized experimentally and isolated in moderate to good yields.

Evaluating Failure Rates of Primary Quadriceps Tendon Repairs Across Different Surgical Techniques.

Background: Quadriceps tendon ruptures occur infrequently in the general population. Biomechanical data suggest advantages with the use of suture anchor fixation for major tendon repair. Clinical studies of quadriceps tendon repair have been limited to small case series.