Effect of chronic administration of alprazolam and adinazolam on clonidine- or apomorphine-induced aggression in laboratory rodents.

The activity of chronic (3 weeks) treatment with the triazolobenzodiazepines, alprazolam and adinazolam, on clonidine- and apomorphine-induced aggression were studied. Adinazolam, like desipramine, potentiated aggression induced by clonidine while diazepam and alprazolam completely abolished it. In the apomorphine-induced aggression, adinazolam suppressed both aggressivity and stereotypy, while diazepam slightly potentiated it.

Difference in learning and retention by Albino Swiss mice. Part III. Effect of some brain stimulants.

According to the two preceding papers, the possible difference in activity of brain stimulants on memory retrieval of "good" and "poor" learning mice was studied. Among the drugs studied, caffeine, oxiracetam and nicotine significantly improved memory recall of poor learning mice. On the contrary, methylphenidate, fipexide and piracetam did not significantly modify memory retention of previously learned avoidance of both poor and good learning mice.