Assessment of 2 cervical screening methods in Mongolia: cervical cytology and visual inspection with acetic acid.

Objective: The aim of the study was to evaluate the test parameters of visual inspection with acetic acid (VIA) and cervical cytology in 3 Mongolian aimags.

Methods: From February 18, 2002, to December 12, 2004, sexually active women, 30 years or older who had never been screened, underwent cervical cytology and VIA in the aimags' central hospital. Women with abnormal test results and 5% of women with normal results were recommended to have colposcopy with or without biopsy.

Risk factors for ovarian cancer and early-onset breast cancer in Mongolia.

Objective: To determine if there are founder BRCA1 mutations in the Mongolian population.

Methods: Seventeen women with ovarian cancer, 14 women with premenopausal breast cancer and one woman with both cancer types were interviewed to obtain family history, and hormonal, reproductive and environment risk factor information. Blood was collected for DNA analysis from these women to determine the frequency of BRCA1 and BRCA2 mutations in Mongolia.

A unique BRCA1 mutation identified in Mongolia.

This is a case report of genetic assessment conducted on a family residing in the third world where two sisters have presented with early onset ovarian cancer. Protein truncation testing and DNA sequencing identified a unique mutation on exon 11 (3452delA) of the BRCA1 gene. Buccal swab testing of three siblings and three offspring showed that half of the family members carried the same mutation.