Adult ADHD. Controlled medication assessment.

Many adults with ADHD respond to stimulant therapy, but controlled medication assessments have not been reported. We administered an effortful working memory task in four half-day sessions, double blind, at methylphenidate levels of 0, 5, 10 and 20 mg. Dose-response curves were established individually.

Adult ADHD. Analysis of self-ratings on a behavior questionnaire.

It is customary to acquire behavior ratings of children with ADHD from parents and teachers, but comparable informants are typically not available for adults. Self-rating is substituted. The present study presents self-ratings of ADHD and control adults on a 43-item scale.

The efficacy and tolerability of venlafaxine and paroxetine in outpatients with depressive disorder or dysthymia.

A 24-week, double-blind, randomized trial was performed to compare the efficacy and tolerability of venlafaxine and paroxetine in patients with major depression or dysthymia. Outpatients aged 18-70 years with a baseline score of 17 on the 21-item Hamilton Depression Rating Scale (HAM-D) were eligible. Patients were randomly assigned to venlafaxine, 37.

Attention deficit disorder in children: three clinical variants.

A clinic-referred population of 116 children with attentional problems was classified by DSM-III [attention deficit disorder (ADD)] with respect to inattention, impulsivity, and hyperactivity. The sample proved to subdivide into three groups: inattentive, impulsive, and hyperactive (HII), n = 60; inattentive and impulsive (II), n = 26; and inattentive (I), n = 30. The distinction between II and I resolves the confounding of impulsivity and inattention in previous studies of children who have ADD but are not hyperactive.