Tissue Clearing and 3D Imaging of Gap Junctions in Rat Uterine Myometrium.

The propagation patterns of electrical activity in the uterus are not well understood. However, the number and size of gap junctions between uterine smooth muscle cells towards the end of pregnancy increases, which may be a catalyst for the onset of the coordinated contractions required for successful labor. In non-pregnancy, there is some evidence that the number and distribution of gap junctions varies throughout the reproductive hormonal cycle.

Validation, bias assessment, and optimization of the UNAFIED 2-year risk prediction model for undiagnosed atrial fibrillation using national electronic health data.

Background: Prediction models for atrial fibrillation (AF) may enable earlier detection and guideline-directed treatment decisions. However, model bias may lead to inaccurate predictions and unintended consequences.

Objective: The purpose of this study was to validate, assess bias, and improve generalizability of "UNAFIED-10," a 2-year, 10-variable predictive model of undiagnosed AF in a national data set (originally developed using the Indiana Network for Patient Care regional data).

IPEM topical report: guidance on 3D printing in radiotherapy.

There has been an increase in the availability and utilization of commercially available 3D printers in radiotherapy, with applications in phantoms, brachytherapy applicators, bolus, compensators, and immobilization devices. Additive manufacturing in the form of 3D printing has the advantage of rapid production of personalized patient specific prints or customized phantoms within a short timeframe. One of the barriers to uptake has been the lack of guidance.

Technical Aspects of a National Service for Paediatric Pelvic Brachytherapy.

Aims: Brachytherapy is advantageous for localised rhabdomyosarcomas in children compared with external beam radiotherapy, sparing close organs at risk with highly conformal dosimetry. A methodology for planning and delivering fractionated high-dose-rate paediatric pelvic brachytherapy is detailed, and the dosimetric parameters are presented. This provides a practical template for radiotherapy departments with a similar patient cohort to implement this treatment technique.

A review of 3D printing utilisation in radiotherapy in the United Kingdom and Republic of Ireland.

The use of three-dimensional (3D) printing in medical applications is quickly becoming mainstream. There have been an increasing number of publications discussing its implementation in radiotherapy, and the technology has become more affordable. The objective of this study was to establish how widely 3D printing is currently being utilised and what has been done to validate the processes and outcomes.