Publications by authors named "G B S Sidhu"

Background: Immune cell-driven inflammation is a key mediator of metabolic dysfunction-associated steatohepatitis (MASH) progression. We have previously demonstrated that pharmacological sphingosine 1-phosphate (S1P) receptor modulation ameliorates MASH and is associated with attenuated accumulation of intrahepatic macrophage and T-cell subsets. Although S1P receptors are expressed on several immune cell types, given the prominent role of monocyte-derived recruited macrophages in the sterile inflammation of MASH, we hypothesized that deletion of S1P receptor 1 (S1P1) on myeloid cells may ameliorate MASH by reducing the accumulation of proinflammatory monocyte-derived macrophages in the liver.

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The major limiting factor of photosynthesis in C3 plants is the enzyme, rubisco which inadequately distinguishes between carbon dioxide and oxygen. To overcome catalytic deficiencies of Rubisco, cyanobacteria utilize advanced protein microcompartments, called the carboxysomes which envelopes the enzymes, Rubisco and Carbonic Anhydrase (CA). These microcompartments facilitate the diffusion of bicarbonate ions which are converted to CO by CA, following in an increase in carbon flux near Rubisco boosting CO fixation process.

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Article Synopsis
  • Early diagnosis of HIV is crucial for starting antiretroviral therapy and preventing further infections, but traditional testing methods require expensive lab equipment and trained staff, which are often lacking in low-resource areas.
  • A new low-cost testing platform has been developed that integrates HIV nucleic acid extraction and amplification in a portable device, allowing for testing without standard lab infrastructure.
  • This platform was validated using both spiked plasma samples and clinical samples, showing effective detection of HIV and the potential for use in point-of-care settings.
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