[Bone marrow aplasia associated with ticlopidine treatment in a patient with idiopathic hypothyroidism].

A new case of severe bone-marrow aplasia due to Ticlopidine therapy is described. On the basis also of immunologic findings, the drug seems to be the cause of the hematologic syndrome. The presence of an idiopathic hypothyroidism may have favored the immune mediated reaction to the drug.

Distinct alpha-L-fucosidase isoenzyme profiles in human leukemic cells.

alpha-L-Fucosidase (EC 3.2.1.

[Immuno-allergic reactions to cotrimoxazole in a hospital population].

By a study of 87 oncologic hospitalized patients, affected by serious infectious complications and treated with high-dose antibiotic therapy including co-trimoxazole, the authors evaluate the allergic and immunologic reactions to the drug on clinical and serological basis and try to outline the pathogenic implicated mechanisms.