Publications by authors named "G B Ivaldi"
Pancreatic cancer (PC) is one of the most aggressive and lethal malignancies, calling for enhanced research. Pancreatic ductal adenocarcinoma (PDAC) represents 70-80% of all cases and is known for its resistance to conventional therapies. Carbon-ion radiotherapy (CIRT) has emerged as a promising approach due to its ability to deliver highly localized doses and unique radiobiological properties compared to X-rays.
View Article and Find Full Text PDFPurpose: Primary gynecological melanomas are uncommon with lower survival rates compared to cutaneous melanomas. Although melanocytes have been identified in a variety of mucosal membranes, little is known about their interactions or roles inside the mucosa layer. Melanin is a common pigment in nature and is endowed with several peculiar chemical, paramagnetic, and semiconductive characteristics.
View Article and Find Full Text PDFArticle Synopsis
- Decellularized ECM bioscaffolds are being explored as a new 3D model for studying radiation effects on cancer cells, specifically radioresistant cell lines HMV-II and PANC-1.
- The study involved irradiating these cells in porcine liver-derived scaffolds with high- and low-energy radiation to evaluate their biological responses in a more realistic in vivo-like environment.
- Results showed that cells maintained their specific characteristics and responded differently to high LET radiation, with Carbon Ions causing more significant damage than photons, indicating that these bioscaffolds could be valuable for future radiobiological research.
Salvage Breast-Conserving Surgery and Reirradiation With Intraoperative Electrons for Recurrent Breast Cancer: A Multicentric Study on Behalf of Italian Association of Radiotherapy and Clinical Oncology (AIRO).
Pract Radiat Oncol
November 2024
Purpose: Intraoperative radiation therapy with electrons (IOERT) may represent a viable choice for partial breast reirradiation after repeat quadrantectomy for local recurrence (LR) for primary breast cancer (BC) in lieu of mastectomy.
Methods And Materials: A database collecting data on partial breast reirradiation with IOERT from 8 Italian centers was set up in 2016 to 2018, providing data on cumulative incidence (CumI) of second LR and survival with a long follow-up.
Results: From 2002 to 2015, 109 patients underwent the conservative retreatment.