Publications by authors named "G B Huffnagle"
Article Synopsis
- The text discusses a specific fungus that survives in the acidic environment of the human stomach, potentially causing conditions like ulcers and gastritis.
- In research on mice, it was found that this fungus can induce localized gastritis without affecting the intestine, highlighting the stomach's vulnerability to fungal infections.
- The study identified immune responses and gene expressions linked to fungal infection in a specific stomach region, suggesting the importance of further research on how this infection interacts with the host's immune system and microbiota.
Article Synopsis
- Scientists studied how certain bacteria affect stomach inflammation in mice, which can be similar to humans.
- They found that the bacteria caused only a little inflammation but made the stomach produce more helpful substances against infections.
- When the mice had a food allergy, their stomachs showed a strong immune response, but the bacteria didn’t make this response worse.
Genome sequence of XZ17, isolated from a C57BL/6J mouse lung.
Microbiol Resour Announc
September 2024
XZ17 was isolated from the lung homogenate of a healthy C57BL/6J mouse. XZ17 is diminished in the lungs of syngeneic bone marrow-transplanted recipient mice. Long-read sequencing of XZ17 yielded a single genome of 1,948,140 bp, with a GC content of 34.
View Article and Find Full Text PDFMicrobiome modifications by steroids during viral exacerbation of asthma and in healthy mice.
Am J Physiol Lung Cell Mol Physiol
November 2024
In the present studies, the assessment of how viral exacerbation of asthmatic responses with and without pulmonary steroid treatment alters the microbiome in conjunction with immune responses presents striking data. The overall findings identify that although steroid treatment of allergic animals diminished the severity of the respiratory syncytial virus (RSV)-induced exacerbation of airway function and mucus hypersecretion, there were local increases in IL-17 expression. Analysis of the lung and gut microbiome suggested that there are differences in RSV exacerbation that are further altered by fluticasone (FLUT) treatment.
View Article and Find Full Text PDFBackground: Respiratory syncytial virus (RSV) infection is a major cause of lower respiratory tract infection, especially in infants, and increases the risk of recurrent wheezing and asthma. Recently, researchers have proposed a possible association between respiratory diseases and microbiome alterations. However, this connection has not been fully established.
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